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2011 ; 15
(2
): 67-77
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Ideal Experimental Rat Models for Liver Diseases
#MMPMID26421020
Lee SW
; Kim SH
; Min SO
; Kim KS
Korean J Hepatobiliary Pancreat Surg
2011[May]; 15
(2
): 67-77
PMID26421020
show ga
There are many limitations for conducting liver disease research in human beings
due to the high cost and potential ethical issues. For this reason, conducting a
study that is difficult to perform in humans using appropriate animal models, can
be beneficial in ascertaining the pathological physiology, and in developing new
treatment modalities. However, it is difficult to determine the appropriate
animal model which is suitable for research purposes, since every patient has
different and diverse clinical symptoms, adverse reactions, and complications due
to the pathological physiology. Also, it is not easy to reproduce identically
various clinical situations in animal models. Recently, the Guide for the Care
and Use of Laboratory Animals has tightened up the regulations, and therefore it
is advisable to select the appropriate animals and decide upon the appropriate
quantities through scientific and systemic considerations before conducting
animal testing. Therefore, in this review article the authors examined various
white rat animal testing models and determined the appropriate usable rat model,
and the pros and cons of its application in liver disease research. The authors
believe that this review will be beneficial in selecting proper laboratory
animals for research purposes.