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2016 ; 10
(ä): 105-9
Nephropedia Template TP
Open Cardiovasc Med J
2016[]; 10
(ä): 105-9
PMID27347227
show ga
Cardiac rhythm abnormalities in the context of epilepsy are a well-known
phenomenon. However, they are under-recognized and often missed. The
pathophysiology of these events is unclear. Bradycardia and asystole are preceded
by seizure onset suggesting ictal propagation into the cortex impacting cardiac
autonomic function, and the insula and amygdala being possible culprits. Sudden
unexpected death in epilepsy (SUDEP) refers to the unanticipated death of a
patient with epilepsy not related to status epilepticus, trauma, drowning, or
suicide. Frequent refractory generalized tonic-clonic seizures, anti-epileptic
polytherapy, and prolonged duration of epilepsy are some of the commonly
identified risk factors for SUDEP. However, the most consistent risk factor out
of these is an increased frequency of generalized tonic-clonic seizures (GTC).
Prevention of SUDEP is extremely important in patients with chronic, generalized
epilepsy. Since increased frequency of GTCS is the most consistently reported
risk factor for SUDEP, effective seizure control is the most important preventive
strategy.