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2015 ; 28
(5
): 525-9
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Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management
#MMPMID26096760
Roberts JK
; Westphal S
; Sparks MA
Semin Dial
2015[Sep]; 28
(5
): 525-9
PMID26096760
show ga
Baclofen is an oral derivative of gamma-aminobutyric acid (GABA) used to treat
muscular spasticity from disorders of the central nervous system. However, it is
also being used for a variety of other conditions such as musculoskeletal pain,
myoclonus, and alcohol withdrawal. The elimination of baclofen is heavily
dependent on intact renal function, and the contraindication for use in patients
with insufficient renal function is not well recognized by healthcare providers.
Here, the authors report a series of mild to severe cases of baclofen
intoxication in patients with end-stage renal disease. In all cases, baclofen was
initiated by either inpatient or outpatient healthcare providers and the patients
generally presented with altered mentation, somnolence, and/or respiratory
depression. All patients were treated with aggressive hemodialysis and made a
full recovery. This paper will briefly review the literature regarding baclofen
intoxication, safety of baclofen use in renal disease, and efficacy of
extracorporeal therapy in the treatment of baclofen intoxication.
|*Renal Dialysis
[MESH]
|Aged
[MESH]
|Baclofen/*adverse effects
[MESH]
|Central Nervous System Diseases/*chemically induced/diagnosis/therapy
[MESH]