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2015 ; 112
(2
): 232-7
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IRAK signalling in cancer
#MMPMID25290089
Rhyasen GW
; Starczynowski DT
Br J Cancer
2015[Jan]; 112
(2
): 232-7
PMID25290089
show ga
Innate immune signalling has an essential role in inflammation, and the
dysregulation of signalling components of this pathway is increasingly being
recognised as an important mediator in cancer initiation and progression. In some
malignancies, dysregulation of inflammatory toll-like receptor (TLR) and
interleukin-1 receptor (IL1R) signalling is typified by increased NF-?B activity,
and it occurs through somatic mutations, chromosomal deletions, and/or
transcriptional deregulation. Interleukin-1 receptor-associated kinase (IRAK)
family members are mediators of TLR/IL1R superfamily signalling, and mounting
evidence implicates these kinases as viable cancer targets. Although there have
been previous efforts aimed at the development of IRAK kinase inhibitors, this is
currently an area of renewed interest for cancer drug development.
|*Signal Transduction
[MESH]
|Animals
[MESH]
|Antineoplastic Agents/pharmacology/therapeutic use
[MESH]
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