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ING5 is a Potential Target for Osteosarcoma Therapy
#MMPMID29528777
Zhang X
; Xu ZH
; Xie H
; Sun YW
; Liu J
; Zhao YB
Technol Cancer Res Treat
2018[Jan]; 17
(?): 1533033818762680
PMID29528777
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Osteosarcoma is one of the most common primary malignant bone tumors. The
inhibitor of growth family of protein 5 has been identified as a tumor suppressor
in many cancers. In this study, we confirmed the downregulation of the both
inhibitor of growth family of protein 5 and messenger RNA levels in cancer
tissues using Western blot and real-time polymerase chain reaction. In order to
find the antitumor roles of inhibitor of growth family of protein 5, osteosarcoma
cells, HOS, and MG63 were transfected with the plasmid pCDNA-3.1-inhibitor of
growth family of protein 5. Overexpression of Inhibitor of growth family of
protein 5 could induce apoptosis and inhibit cell proliferation in osteosarcoma
cells. Furthermore, Western blot analysis showed that p-Smad2, p-Smad3, and Smad4
were increased in inhibitor of growth family of protein 5-expressing osteosarcoma
cells. Our results indicated that overexpression of inhibitor of growth family of
protein 5 in osteosarcoma cells induces apoptosis by activating the Smad pathway,
thus proposing a promising role for inhibitor of growth family of protein 5 in
treatment of patients with osteosarcoma.
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