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2017 ; 8
(3
): 191-201
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IL-25 blockade inhibits metastasis in breast cancer
#MMPMID27909985
Jiang Z
; Chen J
; Du X
; Cheng H
; Wang X
; Dong C
Protein Cell
2017[Mar]; 8
(3
): 191-201
PMID27909985
show ga
Metastasis is the leading cause of death in breast cancer patients. However, the
mechanisms underlying metastasis are not well understood and there is no
effective treatment in the clinic. Here, we demonstrate that in MMTV-PyMT, a
highly malignant spontaneous breast tumor model, IL-25 (also called IL-17E) was
expressed by tumor-infiltrating CD4(+) T cells and macrophages. An IL-25
neutralization antibody, while not affecting primary tumor growth, substantially
reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells
and macrophages in the primary tumor microenvironments, both reported to enhance
breast tumor invasion and subsequent metastasis to the lung. Taken together, our
data suggest IL-25 blockade as a novel treatment for metastatic breast tumor.
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