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10.1093/bfgp/elv050 http://scihub22266oqcxt.onion/10.1093/bfgp/elv050 C4880005!4880005 !26590207     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26590207 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26590207 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Brief+Funct+Genomics 2016 ; 15 (3 ): 174-85 Nephropedia Template TP {{tp|p=26590207 |t=2016. Hypoxic regulation of the noncoding genome and NEAT1 |pdf=|usr=}}{{26590207 }} gab.com Text Hypoxic regulation of the noncoding genome and NEAT1 JO: Brief Funct Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26590207 #FOAvip Activation of hypoxia pathways is both associated with and contributes to an aggressive phenotype across multiple types of solid cancers. The regulation of gene transcription by hypoxia-inducible factor (HIF) is a key element in this response. HIF directly upregulates the expression of many hundreds of protein-coding genes, which act to both improve oxygen delivery and to reduce oxygen demand. However, it is now becoming apparent that many classes of noncoding RNAs are also regulated by hypoxia, with several (e.g. micro RNAs, long noncoding RNAs and antisense RNAs) under direct transcriptional regulation by HIF. These hypoxia-regulated, noncoding RNAs may act as effectors of the indirect response to HIF by acting on specific coding transcripts or by affecting generic RNA-processing pathways. In addition, noncoding RNAs may also act as modulators of the HIF pathway, either by integrating other physiological responses or, in the case of HIF-regulated, noncoding RNAs, by providing negative or positive feedback and feedforward loops that affect upstream or downstream components of the HIF cascade. These hypoxia-regulated, noncoding transcripts play important roles in the aggressive hypoxic phenotype observed in cancer. Twit Text FOAVip Hypoxic regulation of the noncoding genome and NEAT1 ????Brief Funct Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26590207 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26590207 #FOAvip English Wikipedia <ref>{{Cite pmid|26590207 }}</ref> Hypoxic regulation of the noncoding genome and NEAT1 #MMPMID26590207 Choudhry H ; Mole DR Brief Funct Genomics 2016[May]; 15 (3 ): 174-85 PMID26590207 show ga Activation of hypoxia pathways is both associated with and contributes to an aggressive phenotype across multiple types of solid cancers. The regulation of gene transcription by hypoxia-inducible factor (HIF) is a key element in this response. HIF directly upregulates the expression of many hundreds of protein-coding genes, which act to both improve oxygen delivery and to reduce oxygen demand. However, it is now becoming apparent that many classes of noncoding RNAs are also regulated by hypoxia, with several (e.g. micro RNAs, long noncoding RNAs and antisense RNAs) under direct transcriptional regulation by HIF. These hypoxia-regulated, noncoding RNAs may act as effectors of the indirect response to HIF by acting on specific coding transcripts or by affecting generic RNA-processing pathways. In addition, noncoding RNAs may also act as modulators of the HIF pathway, either by integrating other physiological responses or, in the case of HIF-regulated, noncoding RNAs, by providing negative or positive feedback and feedforward loops that affect upstream or downstream components of the HIF cascade. These hypoxia-regulated, noncoding transcripts play important roles in the aggressive hypoxic phenotype observed in cancer. |*Gene Expression Regulation, Neoplastic [MESH] |*Genome, Human [MESH] |Humans [MESH] |Hypoxia/*physiopathology [MESH] |Neoplasms/*genetics/*pathology [MESH]Hypoxic regulation of the noncoding genome and NEAT1 (epmc).pdf DeepDyve Pubget Overpricing