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2004 ; 10
(8
): 1082-7
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Hypoxia-inducible factor-1 in tumour angiogenesis
#MMPMID15069703
Shi YH
; Fang WG
World J Gastroenterol
2004[Apr]; 10
(8
): 1082-7
PMID15069703
show ga
Hypoxia-inducible factor-1 (HIF-1), composed of HIF-alpha and HIF-beta subunits,
is a heterodimeric transcriptional activator. In response to hypoxia, stimulation
of growth factors, and activation of oncogenes as well as carcinogens, HIF-1alpha
is overexpressed and/or activated and targets those genes which are required for
angiogenesis, metabolic adaptation to low oxygen and promotes survival. HIF-1 is
critical for both physiological and pathological processes. Several dozens of
putative direct HIF-1 target genes have been identified on the basis of one or
more cis-acting hypoxia-response elements that contain an HIF-1 binding site. A
variety of regulators including growth factors, genetic alterations, stress
activators, and some carcinogens have been documented for regulation of HIF-1 in
which several signaling pathways are involved depending on the stimuli and cell
types. Activation of HIF-1 in combination with activated signaling pathways and
regulators is implicated in tumour progression and prognosis. This review
presents a summary of the structure and function of HIF-1alpha, and correlation
among specific regulators and their signaling pathways.
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