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10.1146/annurev-physiol-021113-170322 http://scihub22266oqcxt.onion/10.1146/annurev-physiol-021113-170322 C4696033!4696033 !23988176     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23988176 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Physiol 2014 ; 76 (ä): 39-56 Nephropedia Template TP {{tp|p=23988176 |t=2014. Hypoxia-inducible factor 1 and cardiovascular disease |pdf=|usr=}}{{23988176 }} gab.com Text Hypoxia-inducible factor 1 and cardiovascular disease JO: Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23988176 #FOAvip Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis. Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure. Twit Text FOAVip Hypoxia-inducible factor 1 and cardiovascular disease ????Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23988176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23988176 #FOAvip English Wikipedia <ref>{{Cite pmid|23988176 }}</ref> Hypoxia-inducible factor 1 and cardiovascular disease #MMPMID23988176 Semenza GL Annu Rev Physiol 2014[]; 76 (ä): 39-56 PMID23988176 show ga Cardiac function is required for blood circulation and systemic oxygen delivery. However, the heart has intrinsic oxygen demands that must be met to maintain effective contractility. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. HIF-1 controls oxygen delivery, by regulating angiogenesis and vascular remodeling, and oxygen utilization, by regulating glucose metabolism and redox homeostasis. Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure. |Aging/physiology [MESH] |Animals [MESH] |Cardiovascular Diseases/genetics/*physiopathology [MESH] |Heart Failure/physiopathology [MESH] |Homeostasis/physiology [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/metabolism [MESH] |Hypoxia-Inducible Factor 1/genetics/*physiology [MESH] |Ischemic Preconditioning, Myocardial [MESH] |Myocardial Ischemia/genetics/physiopathology [MESH]Hypoxia-inducible factor 1 and cardiovascular disease (epmc).pdf DeepDyve Pubget Overpricing