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10.1007/s40675-017-0062-7 http://scihub22266oqcxt.onion/10.1007/s40675-017-0062-7 C5607450!5607450 !28944164     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28944164 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Sleep+Med+Rep 2017 ; 3 (1 ): 1-10 Nephropedia Template TP {{tp|p=28944164 |t=2017. Hypoxia-Inducible Factors and Cancer |pdf=|usr=}}{{28944164 }} gab.com Text Hypoxia-Inducible Factors and Cancer JO: Curr Sleep Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28944164 #FOAvip PURPOSE OF REVIEW: Hypoxia inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell differentiation. In addition, we examine the proposed relationship between respiratory-related hypoxia, HIFs, and cancer. RECENT FINDINGS: HIFs are increased in many forms of cancer, and portend a poor prognosis and response to therapy. CONCLUSION: HIFs play a critical role in various stages of carcinogenesis. HIF and its transcription targets may be useful as biomarkers of disease and therapeutic targets for cancer. Twit Text FOAVip Hypoxia-Inducible Factors and Cancer ????Curr Sleep Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28944164 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28944164 #FOAvip English Wikipedia <ref>{{Cite pmid|28944164 }}</ref> Hypoxia-Inducible Factors and Cancer #MMPMID28944164 Jun JC ; Rathore A ; Younas H ; Gilkes D ; Polotsky VY Curr Sleep Med Rep 2017[Mar]; 3 (1 ): 1-10 PMID28944164 show ga PURPOSE OF REVIEW: Hypoxia inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell differentiation. In addition, we examine the proposed relationship between respiratory-related hypoxia, HIFs, and cancer. RECENT FINDINGS: HIFs are increased in many forms of cancer, and portend a poor prognosis and response to therapy. CONCLUSION: HIFs play a critical role in various stages of carcinogenesis. HIF and its transcription targets may be useful as biomarkers of disease and therapeutic targets for cancer. äHypoxia-Inducible Factors and Cancer (epmc).pdf DeepDyve Pubget Overpricing