Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24111795
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24111795
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Antioxid+Redox+Signal
2014 ; 21
(8
): 1189-201
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Hypoxamirs and mitochondrial metabolism
#MMPMID24111795
Cottrill KA
; Chan SY
; Loscalzo J
Antioxid Redox Signal
2014[Sep]; 21
(8
): 1189-201
PMID24111795
show ga
SIGNIFICANCE: Chronic hypoxia can drive maladaptive responses in numerous organ
systems, leading to a multitude of chronic mammalian diseases. Oxygen homeostasis
is intimately linked with mitochondrial metabolism, and dysfunction in these
systems can combine to form the backbone of hypoxic-ischemic injury in multiple
tissue beds. Increased appreciation of the crucial roles of hypoxia-associated
miRNA (hypoxamirs) in metabolism adds a new dimension to our understanding of the
regulation of hypoxia-induced disease. RECENT ADVANCES: Myriad factors related to
glycolysis (e.g., aldolase A and hexokinase II), tricarboxylic acid cycle
function (e.g., glutaminase and iron-sulfur cluster assembly protein 1/2), and
apoptosis (e.g., p53) have been recently implicated as targets of hypoxamirs. In
addition, several hypoxamirs have been implicated in the regulation of the master
transcription factor of hypoxia, hypoxia-inducible factor-1?, clarifying how the
cellular program of hypoxia is sustained and resolved. CRITICAL ISSUES: Central
to the discussion of metabolic change in hypoxia is the Warburg effect, a shift
toward anaerobic metabolism that persists after normal oxygen levels have been
restored. Many newly discovered targets of hypoxia-driven microRNA converge on
pathways known to be involved in this pathological phenomenon and the
apoptosis-resistant phenotype associated with it. FUTURE DIRECTIONS: The often
synergistic functions of miRNA may make them ideal therapeutic targets. The use
of antisense inhibitors is currently being considered in diseases in which
hypoxia and metabolic dysregulation predominate. In addition, exploration of
pleiotripic miRNA functions will likely continue to offer unique insights into
the mechanistic relationships of their downstream target pathways and associated
hypoxic phenotypes.
|Animals
[MESH]
|Apoptosis
[MESH]
|Cell Hypoxia
[MESH]
|Electron Transport Chain Complex Proteins/genetics/metabolism
[MESH]
free
free
free
