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10.21037/hbsn.2015.12.13

http://scihub22266oqcxt.onion/10.21037/hbsn.2015.12.13
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C4876248!4876248 !27275463
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suck abstract from ncbi


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pmid27275463
      Hepatobiliary+Surg+Nutr 2016 ; 5 (3 ): 217-24
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  • Hypophosphatemia and recovery of post-hepatectomy liver insufficiency #MMPMID27275463
  • Hallet J ; Karanicolas PJ ; Zih FS ; Cheng E ; Wong J ; Hanna S ; Coburn NG ; Law CH
  • Hepatobiliary Surg Nutr 2016[Jun]; 5 (3 ): 217-24 PMID27275463 show ga
  • BACKGROUND: Hypophosphatemia (HP) is frequent following liver resection, and thought to represent use of phosphate during liver regeneration. We sought to evaluate the association of post-hepatectomy HP with liver insufficiency and recovery. METHODS: Liver resections were retrospectively reviewed from 2009 to 2012 at a single institution. We explored the relationship between HP (defined as serum phosphate ?0.65 mmol/L), occurrence of initial liver insufficiency (ILI) [bilirubin >50 µmol/L, international normalized ratio (INR) >1.7 within 72 hours of surgery] and in-hospital recovery of ILI. Secondary outcomes included 30-day post-operative major morbidity (Clavien grade 3 and 4 complications), mortality, and re-admission. RESULTS: Among 402 patients, 223 (55.5%) experienced HP and 64 (15.9%) met our definition of ILI, of which 53 (82.8%) recovered. Length of stay, 30-day post-operative major morbidity, mortality, and re-admission were similar between patients with and without HP. Among patients with ILI, 44 (68.8%) experienced HP. Following ILI, patients with HP recovered more often than those with NP (90.9% vs. 65.0%; P=0.03). CONCLUSIONS: In patients who experience post-hepatectomy ILI, HP is associated with improved recovery, potentially indicating more efficient liver regeneration. Further studies should explore the usefulness of post-hepatectomy HP as an early prognostic factor of recovery from ILI.
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