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2015 ; 7
(6
): 225-33
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Hyperuricaemia with deposition: latest evidence and therapeutic approach
#MMPMID26622324
Perez-Ruiz F
; Marimon E
; Chinchilla SP
Ther Adv Musculoskelet Dis
2015[Dec]; 7
(6
): 225-33
PMID26622324
show ga
This article reviews recent evidence on urate deposition and the opportunity for
a therapeutic approach. We reviewed Pubmed 2013-2015 literature using the search
terms 'deposition' with 'hyperuricaemia', 'gout', 'ultrasonography', 'DECT'
(dual-energy computed tomography), 'radiography', 'CT'(computed tomography),
'MRI' (magnetic resonance imaging), or 'cardiovascular', in addition to a digital
bibliographic library compiled by the authors with 2072 papers on hyperuricaemia
and gout. Relevant papers on the topic were selected. Recent evidence, mostly
based on imaging studies, showed a continuum from hyperuricaemia to deposition
and clinical manifestations. Chronic inflammation and structural damage may be
present even in asymptomatic patients with crystal-proved deposition. The impact
of early intervention in patients with asymptomatic deposition either on vascular
outcomes or further structural joint damage has not been demonstrated yet. In
conclusion, a worldwide definition of gout is still lacking, stages from
hyperuricaemia to clinical gout not being definitively defined. Although there is
increasing interest on the impact of early deposits on joint damage and
cardiovascular outcomes, robust evidence is still lacking to fully support
interventions.