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2015 ; 24
(2
): 58-66
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Hypersensitivity reactions to modern antiplatelet and anticoagulant drugs
#MMPMID26120548
Hofmeier KS
Allergo J Int
2015[]; 24
(2
): 58-66
PMID26120548
show ga
Anticoagulation and antiplatelet drugs are among the most commonly used medical
drugs. In addition to the long-established heparins, hirudins, coumarins and
antiplatelet drugs such as acetylsalicylic acid, numerous novel and predominantly
synthetic pharmacologic agents have come onto the market in recent years. These
new agents act at various sites in coagulation and have significantly broadened
treatment options. Whilst immunological hypersensitivity reactions are on the
whole rare, they have a considerable impact on patient management when they do
occur. The present overview discusses the currently known hypersensitivity
reactions to anticoagulant and antiplatelet agents, with particular attention to
the newer substance classes including P2Y(12) inhibitors, glycoprotein IIb/IIIb
receptor antagonists, direct factor Xa inhibitors and direct thrombin inhibitors.