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2015 ; 23
(2
): 217-29
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Hyperpolarized Gas MR Imaging: Technique and Applications
#MMPMID25952516
Roos JE
; McAdams HP
; Kaushik SS
; Driehuys B
Magn Reson Imaging Clin N Am
2015[May]; 23
(2
): 217-29
PMID25952516
show ga
Functional imaging offers information more sensitive to changes in lung structure
and function. Hyperpolarized helium ((3)He) and xenon ((129)Xe) MR imaging of the
lungs provides sensitive contrast mechanisms to probe changes in pulmonary
ventilation, microstructure, and gas exchange. Gas imaging has shifted to the use
of (129)Xe. Xenon is well-tolerated. (129)Xe is soluble in pulmonary tissue,
which allows exploring specific lung function characteristics involved in gas
exchange and alveolar oxygenation. Hyperpolarized gases and (129)Xe in particular
stand to be an excellent probe of pulmonary structure and function, and provide
sensitive and noninvasive biomarkers for pulmonary diseases.