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2018 ; 15
(8
): 782-787
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Hyperbaric Oxygen Therapy in Liver Diseases
#MMPMID30008587
Sun Y
; Wen Y
; Shen C
; Zhu Y
; You W
; Meng Y
; Chen L
; Feng Y
; Yang X
; Chen ZB
Int J Med Sci
2018[]; 15
(8
): 782-787
PMID30008587
show ga
Hyperbaric oxygen therapy (HBOT) is an efficient therapeutic option to improve
progress of lots of diseases especially hypoxia-related injuries, and has been
clinically established as a wide-used therapy for patients with carbon monoxide
poisoning, decompression sickness, arterial gas embolism, problematic wound, and
so on. In the liver, most studies positively evaluated HBOT as a potential
therapeutic option for liver transplantation, acute liver injury, nonalcoholic
steatohepatitis, fibrosis and cancer, especially for hepatic artery thrombosis.
This might mainly attribute to the anti-oxidation and anti-inflammation of HBOT.
However, some controversies are existed, possibly due to hyperbaric oxygen
toxicity. This review summarizes the current understandings of the role of HBOT
in liver diseases and hepatic regeneration. Future understanding of HBOT in
clinical trials and its in-depth mechanisms may contribute to the development of
this novel adjuvant strategy for clinical therapy of liver diseases.