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2014 ; 30
(2
): 91-6
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Hydroxyurea in sickle cell disease: drug review
#MMPMID24839362
Agrawal RK
; Patel RK
; Shah V
; Nainiwal L
; Trivedi B
Indian J Hematol Blood Transfus
2014[Jun]; 30
(2
): 91-6
PMID24839362
show ga
Hydroxyurea, a myelosuppressive agent, is the only effective drug proven to
reduce the frequency of painful episodes. It raises the level of HbF and the
haemoglobin level. It usually decreases the rate of painful episodes by 50 %. It
was first tested in sickle cell disease in 1984. It also decreases the rate of
ACS episodes and blood transfusions by ~50 % in adults. It was developed as an
anticancer drug and has been used to treat myeloproliferative syndromes-leukemia,
melanoma, and ovarian cancer. It was approved for use by FDA in adults. Side
effects includes neutropenia, bone marrow suppression, elevation of hepatic
enzymes, anorexia, nausea, vomiting and infertility.