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2012 ; 13
(6
): 064103
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Hydroxylapatite nanoparticles: fabrication methods and medical applications
#MMPMID27877527
Okada M
; Furuzono T
Sci Technol Adv Mater
2012[Dec]; 13
(6
): 064103
PMID27877527
show ga
Hydroxylapatite (or hydroxyapatite, HAp) exhibits excellent biocompatibility with
various kinds of cells and tissues, making it an ideal candidate for tissue
engineering, orthopedic and dental applications. Nanosized materials offer
improved performances compared with conventional materials due to their large
surface-to-volume ratios. This review summarizes existing knowledge and recent
progress in fabrication methods of nanosized (or nanostructured) HAp particles,
as well as their recent applications in medical and dental fields. In section 1,
we provide a brief overview of HAp and nanoparticles. In section 2, fabrication
methods of HAp nanoparticles are described based on the particle formation
mechanisms. Recent applications of HAp nanoparticles are summarized in section 3.
The future perspectives in this active research area are given in section 4.