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2016 ; 25
(13
): 720-731
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Hydrogen Sulfide in Renal Physiology and Disease
#MMPMID27005700
Feliers D
; Lee HJ
; Kasinath BS
Antioxid Redox Signal
2016[Nov]; 25
(13
): 720-731
PMID27005700
show ga
SIGNIFICANCE: Hydrogen sulfide (H2S) has only recently gained recognition for its
physiological effects. It is synthesized widely in the mammalian tissues and
regulates several biologic processes ranging from development, angiogenesis,
neurotransmission to protein synthesis. Recent Advances: The aim of this review
is to critically evaluate the evidence for a role for H2S in kidney function and
disease. CRITICAL ISSUES: H2S regulates fundamental kidney physiologic processes
such as glomerular filtration and sodium reabsorption. In kidney disease states
H2S appears to play a complex role in a context-dependent manner. In some disease
states such as ischemia-reperfusion and diabetic kidney disease it can serve as
an agent that ameliorates kidney injury. In other diseases such as
cis-platinum-induced kidney disease it may mediate kidney injury although more
investigation is needed. Recent studies have revealed that the actions of nitric
oxide and H2S may be integrated in kidney cells. FUTURE DIRECTIONS: Further
studies are needed to understand the full impact of H2S on kidney physiology. As
it is endowed with the properties of regulating blood flow, oxidative stress, and
inflammation, H2S should be investigated for its role in inflammatory and toxic
diseases of the kidney. Such in-depth exploration may identify specific kidney
diseases in which H2S may constitute a unique target for therapeutic
intervention. Antioxid. Redox Signal. 25, 720-731.
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