Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21362136
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21362136
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 FEBS+J
2011 ; 278
(9
): 1412-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Hyaluronan matrices in pathobiological processes
#MMPMID21362136
Wang A
; de la Motte C
; Lauer M
; Hascall V
FEBS J
2011[May]; 278
(9
): 1412-8
PMID21362136
show ga
Hyaluronan matrices are ubiquitous in normal and pathological biological
processes. This remarkable diversity is related to their unique mechanism of
synthesis by hyaluronan synthases. These enzymes are normally activated in the
plasma membrane and utilize cytosolic substrates directly to form these large
polyanionic glycosaminoglycans, which are extruded directly into the
extracellular space. The extracellular matrices that are formed interact with
cell surface receptors, notably CD44, that often dictate the biological
processes, as described in the accompanying minireviews of this series. This
article focuses on the discovery in recent studies that many cell stress
responses initiate the synthesis of a monocyte-adhesive hyaluronan extracellular
matrix, which forms a central focus for subsequent inflammatory processes that
are modulated by the dialogue between the matrix and the inflammatory cells. The
mechanisms involve active hyaluronan synthases at the cell membrane when cell
stresses occur at physiological levels of glucose. However, dividing cells at
hyperglycemic levels of glucose initiate the synthesis of hyaluronan in
intracellular compartments, which induces endoplasmic reticulum stress and
autophagy, processes that probably contribute greatly to diabetic pathologies.
free
free
free
