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2016 ; 9
(ä): 6873-6884
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Hürthle cell carcinoma: current perspectives
#MMPMID27853381
Ahmadi S
; Stang M
; Jiang XS
; Sosa JA
Onco Targets Ther
2016[]; 9
(ä): 6873-6884
PMID27853381
show ga
Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a
widely invasive tumor. HCC generally has a more aggressive clinical behavior
compared with the other differentiated thyroid cancers, and it is associated with
a higher rate of distant metastases. Minimally invasive HCC demonstrates much
less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy
alone, and without radioactive iodine (RAI). HCC has been observed to be less
iodine-avid compared with other differentiated thyroid cancers; however, recent
data have demonstrated improved survival with RAI use in patients with HCC >2 cm
and those with nodal and distant metastases. Patients with localized
iodine-resistant disease who are not candidates for a wait-and-watch approach can
be treated with localized therapies. Systemic therapy is reserved for patients
with progressive, widely metastatic HCC.