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2015 ; 136
(5
): 1378-86.e1-5
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Human seroreactivity to gut microbiota antigens
#MMPMID26014812
Christmann BS
; Abrahamsson TR
; Bernstein CN
; Duck LW
; Mannon PJ
; Berg G
; Björkstén B
; Jenmalm MC
; Elson CO
J Allergy Clin Immunol
2015[Nov]; 136
(5
): 1378-86.e1-5
PMID26014812
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BACKGROUND: Although immune responses directed against antigens from the
intestinal microbiota are observed in certain diseases, the normal human adaptive
immune response to intestinal microbiota is poorly defined. OBJECTIVE: Our goal
was to assess the adaptive immune response to the intestinal microbiota present
in 143 healthy adults and compare this response with the response observed in 52
children and their mothers at risk of having allergic disease. METHODS: Human
serum was collected from adults and children followed from birth to 7 years of
age, and the serum IgG response to a panel of intestinal microbiota antigens was
assessed by using a novel protein microarray. RESULTS: Nearly every subject
tested, regardless of health status, had serum IgG that recognized a common set
of antigens. Seroreactivity to the panel of antigens was significantly lower in
atopic adults. Healthy infants expressed the highest level of IgG seroreactivity
to intestinal microbiota antigens. This adaptive response developed between 6 and
12 months of age and peaked around 2 years of age. Low IgG responses to certain
clusters of microbiota antigens during infancy were associated with allergy
development during childhood. CONCLUSIONS: There is an observed perturbation of
the adaptive response to antigens from the microbiota in allergic subjects. These
perturbations are observable even in childhood, suggesting that optimal
stimulation of the adaptive immune system by the microbiota might be needed to
prevent certain immune-mediated diseases.
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