Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24698483
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Lancet
2014 ; 383
(9936
): 2253-64
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Human schistosomiasis
#MMPMID24698483
Colley DG
; Bustinduy AL
; Secor WE
; King CH
Lancet
2014[Jun]; 383
(9936
): 2253-64
PMID24698483
show ga
Human schistosomiasis--or bilharzia--is a parasitic disease caused by trematode
flukes of the genus Schistosoma. By conservative estimates, at least 230 million
people worldwide are infected with Schistosoma spp. Adult schistosome worms
colonise human blood vessels for years, successfully evading the immune system
while excreting hundreds to thousands of eggs daily, which must either leave the
body in excreta or become trapped in nearby tissues. Trapped eggs induce a
distinct immune-mediated granulomatous response that causes local and systemic
pathological effects ranging from anaemia, growth stunting, impaired cognition,
and decreased physical fitness, to organ-specific effects such as severe
hepatosplenism, periportal fibrosis with portal hypertension, and urogenital
inflammation and scarring. At present, preventive public health measures in
endemic regions consist of treatment once every 1 or 2 years with the
isoquinolinone drug, praziquantel, to suppress morbidity. In some locations,
elimination of transmission is now the goal; however, more sensitive diagnostics
are needed in both the field and clinics, and integrated environmental and
health-care management will be needed to ensure elimination.
|Adolescent
[MESH]
|Adult
[MESH]
|Age Distribution
[MESH]
|Aged
[MESH]
|Animals
[MESH]
|Child
[MESH]
|Child, Preschool
[MESH]
|Communicable Disease Control/methods
[MESH]
|Cost of Illness
[MESH]
|Female
[MESH]
|Global Health
[MESH]
|Humans
[MESH]
|Immunity, Cellular
[MESH]
|Infant
[MESH]
|Life Cycle Stages/physiology
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Parasite Egg Count
[MESH]
|Schistosoma/growth & development
[MESH]
|Schistosomiasis/diagnosis/epidemiology/*prevention & control
[MESH]
free
free
free
