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2014 ; 20
(6
): 991-9
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Human polyomavirus 9 infection in kidney transplant patients
#MMPMID24866095
van der Meijden E
; Wunderink HF
; van der Blij-de Brouwer CS
; Zaaijer HL
; Rotmans JI
; Bavinck JN
; Feltkamp MC
Emerg Infect Dis
2014[Jun]; 20
(6
): 991-9
PMID24866095
show ga
Several human polyomaviruses of unknown prevalence and pathogenicity have been
identified, including human polyomavirus 9 (HPyV9). To determine rates of HPyV9
infection among immunosuppressed patients, we screened serum samples from 101
kidney transplant patients in the Netherlands for HPyV9 DNA and seroreactivity. A
total of 21 patients had positive results for HPyV9 DNA; positivity rates peaked
at 3 months after transplantation, but the highest viral loads were measured just
after transplantation. During 18 months of follow-up, HPyV9 seroprevalence
increased from 33% to 46% among transplant patients; seroprevalence remained
stable at ?30% in a control group of healthy blood donors in whom no HPyV9 DNA
was detected. Further analysis revealed an association between detection of HPyV9
and detection of BK polyomavirus but not of cytomegalovirus. Our data indicate
that HPyV9 infection is frequent in kidney transplant patients, but the nature of
infection-endogenous or donor-derived-and pathogenic potential of this virus
remain unknown.
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