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10.1016/j.gde.2016.03.005 http://scihub22266oqcxt.onion/10.1016/j.gde.2016.03.005 C5055853!5055853 !27065468     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27065468 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Genet+Dev 2016 ; 38 (ä): 52-62 Nephropedia Template TP {{tp|p=27065468 |t=2016. Human mitochondrial DNA replication machinery and disease |pdf=|usr=}}{{27065468 }} gab.com Text Human mitochondrial DNA replication machinery and disease JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=27065468 #FOAvip The human mitochondrial genome is replicated by DNA polymerase ? in concert with key components of the mitochondrial DNA (mtDNA) replication machinery. Defects in mtDNA replication or nucleotide metabolism cause deletions, point mutations, or depletion of mtDNA. The resulting loss of cellular respiration ultimately induces mitochondrial genetic diseases, including mtDNA depletion syndromes (MDS) such as Alpers or early infantile hepatocerebral syndromes, and mtDNA deletion disorders such as progressive external ophthalmoplegia, ataxia-neuropathy, or mitochondrial neurogastrointestinal encephalomyopathy. Here we review the current literature regarding human mtDNA replication and heritable disorders caused by genetic changes of the POLG, POLG2, Twinkle, RNASEH1, DNA2, and MGME1 genes. Twit Text FOAVip Human mitochondrial DNA replication machinery and disease ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=27065468 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27065468 #FOAvip English Wikipedia <ref>{{Cite pmid|27065468 }}</ref> Human mitochondrial DNA replication machinery and disease #MMPMID27065468 Young MJ ; Copeland WC Curr Opin Genet Dev 2016[Jun]; 38 (ä): 52-62 PMID27065468 show ga The human mitochondrial genome is replicated by DNA polymerase ? in concert with key components of the mitochondrial DNA (mtDNA) replication machinery. Defects in mtDNA replication or nucleotide metabolism cause deletions, point mutations, or depletion of mtDNA. The resulting loss of cellular respiration ultimately induces mitochondrial genetic diseases, including mtDNA depletion syndromes (MDS) such as Alpers or early infantile hepatocerebral syndromes, and mtDNA deletion disorders such as progressive external ophthalmoplegia, ataxia-neuropathy, or mitochondrial neurogastrointestinal encephalomyopathy. Here we review the current literature regarding human mtDNA replication and heritable disorders caused by genetic changes of the POLG, POLG2, Twinkle, RNASEH1, DNA2, and MGME1 genes. |*Genome, Mitochondrial [MESH] |Cell Respiration/genetics [MESH] |DNA Helicases/genetics [MESH] |DNA Polymerase gamma [MESH] |DNA Replication/*genetics [MESH] |DNA, Mitochondrial/*genetics [MESH] |DNA-Directed DNA Polymerase/genetics [MESH] |Exodeoxyribonucleases/genetics [MESH] |Humans [MESH] |Mitochondrial Diseases/*genetics/pathology [MESH] |Mitochondrial Proteins/genetics [MESH] |Mutation [MESH]Human mitochondrial DNA replication machinery and disease (epmc).pdf DeepDyve Pubget Overpricing