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2018 ; 7
(ä): 135
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Human metapneumovirus - what we know now
#MMPMID29744035
Shafagati N
; Williams J
F1000Res
2018[]; 7
(ä): 135
PMID29744035
show ga
Human metapneumovirus (HMPV) is a leading cause of acute respiratory infection,
particularly in children, immunocompromised patients, and the elderly. HMPV,
which is closely related to avian metapneumovirus subtype C, has circulated for
at least 65 years, and nearly every child will be infected with HMPV by the age
of 5. However, immunity is incomplete, and re-infections occur throughout adult
life. Symptoms are similar to those of other respiratory viral infections,
ranging from mild (cough, rhinorrhea, and fever) to more severe (bronchiolitis
and pneumonia). The preferred method for diagnosis is reverse
transcription-polymerase chain reaction as HMPV is difficult to culture. Although
there have been many advances made in the past 16 years since its discovery,
there are still no US Food and Drug Administration-approved antivirals or
vaccines available to treat HMPV. Both small animal and non-human primate models
have been established for the study of HMPV. This review will focus on the
epidemiology, transmission, and clinical manifestations in humans as well as the
animal models of HMPV pathogenesis and host immune response.
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