Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=2513295
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\2513295
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Jpn+J+Cancer+Res
1989 ; 80
(9
): 795-807
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Human carcinogens so far identified
#MMPMID2513295
Tomatis L
; Aitio A
; Wilbourn J
; Shuker L
Jpn J Cancer Res
1989[Sep]; 80
(9
): 795-807
PMID2513295
show ga
The massive exploitation of natural resources, of which tobacco and asbestos are
two conspicuous, though very different examples, and the synthesis of industrial
chemicals have generated new hazards and new carcinogens which have been added to
older ones. The majority of the over 50 agents that have been firmly identified
so far as being human carcinogens belong to the relatively new hazards, that is
environmental chemicals or chemical mixtures to which humans have been exposed
only during the last century and a half. They are of more importance for cancer
occurring in men than in women, and there is no evidence so far that they are
related to cancers occurring at some of the most common target sites in either
sex. It would be mistaken to believe that complete cancer prevention could be
achieved solely by controlling these new, or relatively new, carcinogenic agents,
but it would be similarly wrong to deny the importance of trying to control them
and of continuing to do so. The experimental approach for the identification of
carcinogens has an irreplaceable role to play in preventing the dispersal into
our environment of new hazards and in identifying among the chemicals already in
use, those that are carcinogenic. That a closer integration between the
epidemiological and the experimental approaches may succeed in substantially
reducing the size of the unknown region within the spectrum of cancer-causing
factors, is today's hope that awaits confirmation. At the same time, advances in
the understanding of the mechanisms underlying the different steps of the process
leading to the clinical manifestation of cancer may help in the uncovering of
agents and risk factors that the approaches used, at least in the way they have
been used until now, may not have been apt to identify.
|Animals
[MESH]
|Carcinogenicity Tests
[MESH]
|Carcinogens, Environmental/*toxicity
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Male
[MESH]
|Mutagenicity Tests
[MESH]
|Neoplasms/*chemically induced/prevention & control
[MESH]