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Cilia
2016 ; 5
(?): 13
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English Wikipedia
Human basal body basics
#MMPMID26981235
Vertii A
; Hung HF
; Hehnly H
; Doxsey S
Cilia
2016[]; 5
(?): 13
PMID26981235
show ga
In human cells, the basal body (BB) core comprises a ninefold microtubule-triplet
cylindrical structure. Distal and subdistal appendages are located at the distal
end of BB, where they play indispensable roles in cilium formation and function.
Most cells that arrest in the G0 stage of the cell cycle initiate BB docking at
the plasma membrane followed by BB-mediated growth of a solitary primary cilium,
a structure required for sensing the extracellular environment and cell
signaling. In addition to the primary cilium, motile cilia are present in
specialized cells, such as sperm and airway epithelium. Mutations that affect BB
function result in cilia dysfunction. This can generate syndromic disorders,
collectively called ciliopathies, for which there are no effective treatments. In
this review, we focus on the features and functions of BBs and centrosomes in
Homo sapiens.
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