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10.1074/jbc.M115.645812 http://scihub22266oqcxt.onion/10.1074/jbc.M115.645812 C4481200!4481200 !25861985     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25861985 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (26 ): 15949-60 Nephropedia Template TP {{tp|p=25861985 |t=2015. Human Urinary Composition Controls Antibacterial Activity of Siderocalin |pdf=|usr=}}{{25861985 }} gab.com Text Human Urinary Composition Controls Antibacterial Activity of Siderocalin JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25861985 #FOAvip During Escherichia coli urinary tract infections, cells in the human urinary tract release the antimicrobial protein siderocalin (SCN; also known as lipocalin 2, neutrophil gelatinase-associated lipocalin/NGAL, or 24p3). SCN can interfere with E. coli iron acquisition by sequestering ferric iron complexes with enterobactin, the conserved E. coli siderophore. Here, we find that human urinary constituents can reverse this relationship, instead making enterobactin critical for overcoming SCN-mediated growth restriction. Urinary control of SCN activity exhibits wide ranging individual differences. We used these differences to identify elevated urinary pH and aryl metabolites as key biochemical host factors controlling urinary SCN activity. These aryl metabolites are well known products of intestinal microbial metabolism. Together, these results identify an innate antibacterial immune interaction that is critically dependent upon individualistic chemical features of human urine. Twit Text FOAVip Human Urinary Composition Controls Antibacterial Activity of Siderocalin ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25861985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25861985 #FOAvip English Wikipedia <ref>{{Cite pmid|25861985 }}</ref> Human Urinary Composition Controls Antibacterial Activity of Siderocalin #MMPMID25861985 Shields-Cutler RR ; Crowley JR ; Hung CS ; Stapleton AE ; Aldrich CC ; Marschall J ; Henderson JP J Biol Chem 2015[Jun]; 290 (26 ): 15949-60 PMID25861985 show ga During Escherichia coli urinary tract infections, cells in the human urinary tract release the antimicrobial protein siderocalin (SCN; also known as lipocalin 2, neutrophil gelatinase-associated lipocalin/NGAL, or 24p3). SCN can interfere with E. coli iron acquisition by sequestering ferric iron complexes with enterobactin, the conserved E. coli siderophore. Here, we find that human urinary constituents can reverse this relationship, instead making enterobactin critical for overcoming SCN-mediated growth restriction. Urinary control of SCN activity exhibits wide ranging individual differences. We used these differences to identify elevated urinary pH and aryl metabolites as key biochemical host factors controlling urinary SCN activity. These aryl metabolites are well known products of intestinal microbial metabolism. Together, these results identify an innate antibacterial immune interaction that is critically dependent upon individualistic chemical features of human urine. |Carrier Proteins/*immunology [MESH] |Enterobactin/metabolism [MESH] |Escherichia coli Infections/*immunology/microbiology [MESH] |Escherichia coli/*immunology/metabolism [MESH] |Humans [MESH] |Hydrogen-Ion Concentration [MESH] |Iron/metabolism [MESH] |Lipocalin-2 [MESH] |Siderophores/metabolism [MESH] |Urinary Tract Infections/*immunology/microbiology [MESH]Human Urinary Composition Controls Antibacterial Activity of Siderocal(epmc).pdf DeepDyve Pubget Overpricing