Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27211305
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27211305
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Trends+Mol+Med
2016 ; 22
(6
): 511-527
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Human TBK1: A Gatekeeper of Neuroinflammation
#MMPMID27211305
Ahmad L
; Zhang SY
; Casanova JL
; Sancho-Shimizu V
Trends Mol Med
2016[Jun]; 22
(6
): 511-527
PMID27211305
show ga
The importance of TANK binding kinase-1 (TBK1), a multimeric kinase that
modulates inflammation and autophagy, in human health has been highlighted for
the first time by the recent discoveries of mutations in TBK1 that underlie
amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), normal
tension glaucoma (NTG) or childhood herpes simplex encephalitis (HSE).
Gain-of-function of TBK1 are associated with NTG, whereas loss-of-function
mutations result in ALS/FTD or in HSE. In light of these new findings, we review
the role of TBK1 in these seemingly unrelated, yet allelic diseases, and discuss
the role of TBK1 in neuroinflammatory diseases. This discovery has the potential
to significantly increase our understanding of the molecular basis of these
poorly understood diseases.
free
free
free
