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2015 ; 7
(6
): 563-71
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Human Cytokine-Induced Memory-Like Natural Killer Cells
#MMPMID25924651
Berrien-Elliott MM
; Wagner JA
; Fehniger TA
J Innate Immun
2015[]; 7
(6
): 563-71
PMID25924651
show ga
Natural killer (NK) cells are innate lymphoid cells that are important for host
defense against infection and mediate antitumor responses. Recent reports from
several laboratories have identified that NK cells can remember a prior
activation event and consequently respond more robustly when restimulated, a
property termed innate NK cell memory. NK cell memory has now been identified
following hapten exposure, viral infection, and combined cytokine preactivation
with IL-12, IL-15, and IL-18. Many questions in the field remain regarding the
cellular and molecular mechanisms regulating memory NK cells and their responses,
as well as their formation and function in mice and humans. Here we review our
current understanding of cytokine-induced memory-like (CIML) NK cells that are
generated by combined preactivation with IL-12, IL-15, and IL-18. These cells
exhibit enhanced NK cell effector functions weeks after the initial cytokine
preactivation. Further, we highlight the preclinical rationale and ongoing
therapeutic application of CIML NK cells for adoptive immunotherapy in patients
with hematologic malignancies.
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