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10.1158/0008-5472.CAN-14-0747 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-0747 C4174322!4174322 !24994713     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24994713 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24994713 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Res 2014 ; 74 (17 ): 4731-40 Nephropedia Template TP {{tp|p=24994713 |t=2014. Hsp70-Bag3 interactions regulate cancer-related signaling networks |pdf=|usr=}}{{24994713 }} gab.com Text Hsp70-Bag3 interactions regulate cancer-related signaling networks JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24994713 #FOAvip Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here, we report that Bag3 interacts with the SH3 domain of Src, thereby mediating the effects of Hsp70 on Src signaling. Using several complementary approaches, we established that the Hsp70-Bag3 module is a broad-acting regulator of cancer cell signaling by modulating the activity of the transcription factors NF-?B, FoxM1, Hif1?, the translation regulator HuR, and the cell-cycle regulators p21 and survivin. We also identified a small-molecule inhibitor, YM-1, that disrupts the Hsp70-Bag3 interaction. YM-1 mirrored the effects of Hsp70 depletion on these signaling pathways, and in vivo administration of this drug was sufficient to suppress tumor growth in mice. Overall, our results defined Bag3 as a critical factor in Hsp70-modulated signaling and offered a preclinical proof-of-concept that the Hsp70-Bag3 complex may offer an appealing anticancer target. Twit Text FOAVip Hsp70-Bag3 interactions regulate cancer-related signaling networks ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24994713 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24994713 #FOAvip English Wikipedia <ref>{{Cite pmid|24994713 }}</ref> Hsp70-Bag3 interactions regulate cancer-related signaling networks #MMPMID24994713 Colvin TA ; Gabai VL ; Gong J ; Calderwood SK ; Li H ; Gummuluru S ; Matchuk ON ; Smirnova SG ; Orlova NV ; Zamulaeva IA ; Garcia-Marcos M ; Li X ; Young ZT ; Rauch JN ; Gestwicki JE ; Takayama S ; Sherman MY Cancer Res 2014[Sep]; 74 (17 ): 4731-40 PMID24994713 show ga Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here, we report that Bag3 interacts with the SH3 domain of Src, thereby mediating the effects of Hsp70 on Src signaling. Using several complementary approaches, we established that the Hsp70-Bag3 module is a broad-acting regulator of cancer cell signaling by modulating the activity of the transcription factors NF-?B, FoxM1, Hif1?, the translation regulator HuR, and the cell-cycle regulators p21 and survivin. We also identified a small-molecule inhibitor, YM-1, that disrupts the Hsp70-Bag3 interaction. YM-1 mirrored the effects of Hsp70 depletion on these signaling pathways, and in vivo administration of this drug was sufficient to suppress tumor growth in mice. Overall, our results defined Bag3 as a critical factor in Hsp70-modulated signaling and offered a preclinical proof-of-concept that the Hsp70-Bag3 complex may offer an appealing anticancer target. |Adaptor Proteins, Signal Transducing/*genetics [MESH] |Animals [MESH] |Apoptosis Regulatory Proteins/*genetics [MESH] |Cell Line [MESH] |Cell Line, Tumor [MESH] |Cyclin-Dependent Kinase Inhibitor p21/genetics [MESH] |ELAV Proteins/genetics [MESH] |ELAV-Like Protein 1 [MESH] |Female [MESH] |Forkhead Box Protein M1 [MESH] |Forkhead Transcription Factors/genetics [MESH] |HCT116 Cells [MESH] |HEK293 Cells [MESH] |HSP72 Heat-Shock Proteins/*genetics [MESH] |HeLa Cells [MESH] |Humans [MESH] |Inhibitor of Apoptosis Proteins/genetics [MESH] |MCF-7 Cells [MESH] |Melanoma, Experimental [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Nude [MESH] |NF-kappa B/genetics [MESH] |Signal Transduction/*genetics [MESH] |Survivin [MESH]Hsp70-Bag3 interactions regulate cancer-related signaling networks (epmc).pdf DeepDyve Pubget Overpricing