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10.1161/CIRCRESAHA.116.306374 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.116.306374 C4443843!4443843 !25999423     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25999423 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Circ+Res 2015 ; 116 (11 ): 1835-49 Nephropedia Template TP {{tp|p=25999423 |t=2015. How mitochondrial dynamism orchestrates mitophagy |pdf=|usr=}}{{25999423 }} gab.com Text How mitochondrial dynamism orchestrates mitophagy JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=25999423 #FOAvip Mitochondria are highly dynamic, except in adult cardiomyocytes. Yet, the fission and fusion-promoting proteins that mediate mitochondrial dynamism are highly expressed in, and essential to the normal functioning of, hearts. Here, we review accumulating evidence supporting important roles for mitochondrial fission and fusion in cardiac mitochondrial quality control, focusing on the PTEN-induced putative kinase 1-Parkin mitophagy pathway. Based in part on recent findings from in vivo mouse models in which mitofusin-mediated mitochondrial fusion or dynamin-related protein 1-mediated mitochondrial fission was conditionally interrupted in cardiac myocytes, we propose several new concepts that may provide insight into the cardiac mitochondrial dynamism-mitophagy interactome. Twit Text FOAVip How mitochondrial dynamism orchestrates mitophagy ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=25999423 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25999423 #FOAvip English Wikipedia <ref>{{Cite pmid|25999423 }}</ref> How mitochondrial dynamism orchestrates mitophagy #MMPMID25999423 Shirihai OS ; Song M ; Dorn GW 2nd Circ Res 2015[May]; 116 (11 ): 1835-49 PMID25999423 show ga Mitochondria are highly dynamic, except in adult cardiomyocytes. Yet, the fission and fusion-promoting proteins that mediate mitochondrial dynamism are highly expressed in, and essential to the normal functioning of, hearts. Here, we review accumulating evidence supporting important roles for mitochondrial fission and fusion in cardiac mitochondrial quality control, focusing on the PTEN-induced putative kinase 1-Parkin mitophagy pathway. Based in part on recent findings from in vivo mouse models in which mitofusin-mediated mitochondrial fusion or dynamin-related protein 1-mediated mitochondrial fission was conditionally interrupted in cardiac myocytes, we propose several new concepts that may provide insight into the cardiac mitochondrial dynamism-mitophagy interactome. |*Mitochondrial Dynamics [MESH] |*Mitophagy [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Dynamins/metabolism [MESH] |Humans [MESH] |Mitochondria, Heart/*metabolism [MESH] |Models, Biological [MESH] |Protein Kinases/metabolism [MESH]How mitochondrial dynamism orchestrates mitophagy (epmc).pdf DeepDyve Pubget Overpricing