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10.1158/2159-8290.CD-17-0550 http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-17-0550 C5630089!5630089 !28923911     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28923911 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Discov 2017 ; 7 (10 ): 1069-1087 Nephropedia Template TP {{tp|p=28923911 |t=2017. How Ribosomes Translate Cancer |pdf=|usr=}}{{28923911 }} gab.com Text How Ribosomes Translate Cancer JO: Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=28923911 #FOAvip A wealth of novel findings, including congenital ribosomal mutations in ribosomopathies and somatic ribosomal mutations in various cancers, have significantly increased our understanding of the relevance of ribosomes in oncogenesis. Here, we explore the growing list of mechanisms by which the ribosome is involved in carcinogenesis-from the hijacking of ribosomes by oncogenic factors and dysregulated translational control, to the effects of mutations in ribosomal components on cellular metabolism. Of clinical importance, the recent success of RNA polymerase inhibitors highlights the dependence on "onco-ribosomes" as an Achilles' heel of cancer cells and a promising target for further therapeutic intervention.Significance: The recent discovery of somatic mutations in ribosomal proteins in several cancers has strengthened the link between ribosome defects and cancer progression, while also raising the question of which cellular mechanisms such defects exploit. Here, we discuss the emerging molecular mechanisms by which ribosomes support oncogenesis, and how this understanding is driving the design of novel therapeutic strategies. Cancer Discov; 7(10); 1069-87. ©2017 AACR. Twit Text FOAVip How Ribosomes Translate Cancer ????Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=28923911 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28923911 #FOAvip English Wikipedia <ref>{{Cite pmid|28923911 }}</ref> How Ribosomes Translate Cancer #MMPMID28923911 Sulima SO ; Hofman IJF ; De Keersmaecker K ; Dinman JD Cancer Discov 2017[Oct]; 7 (10 ): 1069-1087 PMID28923911 show ga A wealth of novel findings, including congenital ribosomal mutations in ribosomopathies and somatic ribosomal mutations in various cancers, have significantly increased our understanding of the relevance of ribosomes in oncogenesis. Here, we explore the growing list of mechanisms by which the ribosome is involved in carcinogenesis-from the hijacking of ribosomes by oncogenic factors and dysregulated translational control, to the effects of mutations in ribosomal components on cellular metabolism. Of clinical importance, the recent success of RNA polymerase inhibitors highlights the dependence on "onco-ribosomes" as an Achilles' heel of cancer cells and a promising target for further therapeutic intervention.Significance: The recent discovery of somatic mutations in ribosomal proteins in several cancers has strengthened the link between ribosome defects and cancer progression, while also raising the question of which cellular mechanisms such defects exploit. Here, we discuss the emerging molecular mechanisms by which ribosomes support oncogenesis, and how this understanding is driving the design of novel therapeutic strategies. Cancer Discov; 7(10); 1069-87. ©2017 AACR. |*Mutation [MESH] |Animals [MESH] |Disease Progression [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Neoplasms/*genetics/metabolism [MESH]How Ribosomes Translate Cancer (epmc).pdf DeepDyve Pubget Overpricing