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How Rab proteins determine Golgi structure
#MMPMID25708460
Liu S
; Storrie B
Int Rev Cell Mol Biol
2015[]; 315
(?): 1-22
PMID25708460
show ga
Rab proteins, small GTPases, are key regulators of mammalian Golgi apparatus
organization. Based on the effect of Rab activation state, Rab proteins fall into
two functional classes. In Class1, inactivation induces Golgi ribbon
fragmentation and/or redistribution of Golgi enzymes to the Endoplasmic
Reticulum, while overexpression of wild type or activation has little, if any,
effect on Golgi ribbon organization. In Class 2, the reverse is true. We give
emphasis to Rab6, the most abundant Golgi-associated Rab protein. Rab6 depletion
in HeLa cells causes an increase in Golgi cisternal number, longer, more
continuous cisternae, and a pronounced accumulation of vesicles; the effect of
Rab6 on Golgi ribbon organization is probably through regulation of vesicle
transport. In effector studies, motor proteins and their regulators are found to
be key Rab6 effectors. A related Rab, Rab41, affects Golgi ribbon organization in
a contrasting manner. The balance between minus- and plus-end directed motor
recruitment may well be the major Rab-dependent factor in Golgi ribbon
organization.
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