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2015 ; 6
(ä): 471
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How Neutrophils Shape Adaptive Immune Responses
#MMPMID26441976
Leliefeld PH
; Koenderman L
; Pillay J
Front Immunol
2015[]; 6
(ä): 471
PMID26441976
show ga
Neutrophils are classically considered as cells pivotal for the first line of
defense against invading pathogens. In recent years, evidence has accumulated
that they are also important in the orchestration of adaptive immunity.
Neutrophils rapidly migrate in high numbers to sites of inflammation (e.g.,
infection, tissue damage, and cancer) and are subsequently able to migrate to
draining lymph nodes (LNs). Both at the site of inflammation as well as in the
LNs, neutrophils can engage with lymphocytes and antigen-presenting cells. This
crosstalk occurs either directly via cell-cell contact or via mediators, such as
proteases, cytokines, and radical oxygen species. In this review, we will discuss
the current knowledge regarding locations and mechanisms of interaction between
neutrophils and lymphocytes in the context of homeostasis and various
pathological conditions. In addition, we will highlight the complexity of the
microenvironment that is involved in the generation of suppressive or stimulatory
neutrophil phenotypes.