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2015 ; 125
(23
): 3551-8
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How I treat priapism
#MMPMID25810489
Anele UA
; Le BV
; Resar LM
; Burnett AL
Blood
2015[Jun]; 125
(23
): 3551-8
PMID25810489
show ga
Priapism is a disorder of persistent penile erection unrelated to sexual interest
or desire. This pathologic condition, specifically the ischemic variant, is often
associated with devastating complications, notably erectile dysfunction. Because
priapism demonstrates high prevalence in patients with hematologic disorders,
most commonly sickle cell disease (SCD), there is significant concern for its
sequelae in this affected population. Thus, timely diagnosis and management are
critical for the prevention or at least reduction of cavernosal tissue ischemia
and potential damage consequent to each episode. Current guidelines and
management strategies focus primarily on reactive treatments. However, an
increasing understanding of the molecular pathophysiology of SCD-associated
priapism has led to the identification of new potential therapeutic targets.
Future agents are being developed and explored for use in the prevention of
priapism.