Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.celrep.2018.03.069 http://scihub22266oqcxt.onion/10.1016/j.celrep.2018.03.069 C5965297!5965297 !29642007     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29642007 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29642007 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2018 ; 23 (2 ): 499-511 Nephropedia Template TP {{tp|p=29642007 |t=2018. How Biophysical Forces Regulate Human B Cell Lymphomas |pdf=|usr=}}{{29642007 }} gab.com Text How Biophysical Forces Regulate Human B Cell Lymphomas JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29642007 #FOAvip The role of microenvironment-mediated biophysical forces in human lymphomas remains elusive. Diffuse large B cell lymphomas (DLBCLs) are heterogeneous tumors, which originate from highly proliferative germinal center B cells. These tumors, their associated neo-vessels, and lymphatics presumably expose cells to particular fluid flow and survival signals. Here, we show that fluid flow enhances proliferation and modulates response of DLBCLs to specific therapeutic agents. Fluid flow upregulates surface expression of B cell receptors (BCRs) and integrin receptors in subsets of ABC-DLBCLs with either CD79A/B mutations or WT BCRs, similar to what is observed with xenografted human tumors in mice. Fluid flow differentially upregulates signaling targets, such as SYK and p70S6K, in ABC-DLBCLs. By selective knockdown of CD79B and inhibition of signaling targets, we provide mechanistic insights into how fluid flow mechanomodulates BCRs and integrins in ABC-DLBCLs. These findings redefine microenvironment factors that regulate lymphoma-drug interactions and will be critical for testing targeted therapies. Twit Text FOAVip How Biophysical Forces Regulate Human B Cell Lymphomas ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29642007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29642007 #FOAvip English Wikipedia <ref>{{Cite pmid|29642007 }}</ref> How Biophysical Forces Regulate Human B Cell Lymphomas #MMPMID29642007 Apoorva F ; Loiben AM ; Shah SB ; Purwada A ; Fontan L ; Goldstein R ; Kirby BJ ; Melnick AM ; Cosgrove BD ; Singh A Cell Rep 2018[Apr]; 23 (2 ): 499-511 PMID29642007 show ga The role of microenvironment-mediated biophysical forces in human lymphomas remains elusive. Diffuse large B cell lymphomas (DLBCLs) are heterogeneous tumors, which originate from highly proliferative germinal center B cells. These tumors, their associated neo-vessels, and lymphatics presumably expose cells to particular fluid flow and survival signals. Here, we show that fluid flow enhances proliferation and modulates response of DLBCLs to specific therapeutic agents. Fluid flow upregulates surface expression of B cell receptors (BCRs) and integrin receptors in subsets of ABC-DLBCLs with either CD79A/B mutations or WT BCRs, similar to what is observed with xenografted human tumors in mice. Fluid flow differentially upregulates signaling targets, such as SYK and p70S6K, in ABC-DLBCLs. By selective knockdown of CD79B and inhibition of signaling targets, we provide mechanistic insights into how fluid flow mechanomodulates BCRs and integrins in ABC-DLBCLs. These findings redefine microenvironment factors that regulate lymphoma-drug interactions and will be critical for testing targeted therapies. |Animals [MESH] |Apoptosis/drug effects [MESH] |CD79 Antigens/antagonists & inhibitors/genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Cytokines/metabolism [MESH] |Doxorubicin/pharmacology [MESH] |Humans [MESH] |Integrins/metabolism [MESH] |Lymphoma, Large B-Cell, Diffuse/*metabolism/pathology [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Microfluidics/instrumentation/methods [MESH] |RNA Interference [MESH] |RNA, Small Interfering/metabolism [MESH] |Receptors, Antigen, B-Cell/genetics/*metabolism [MESH] |Shear Strength [MESH] |Signal Transduction [MESH] |Tumor Microenvironment [MESH] |Up-Regulation [MESH]How Biophysical Forces Regulate Human B Cell Lymphomas (epmc).pdf DeepDyve Pubget Overpricing