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10.1111/imr.12508 http://scihub22266oqcxt.onion/10.1111/imr.12508 C5479487!5479487 !28133807     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28133807 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunol+Rev 2017 ; 275 (1 ): 79-88 Nephropedia Template TP {{tp|p=28133807 |t=2017. Host controls of HIV broadly neutralizing antibody development |pdf=|usr=}}{{28133807 }} gab.com Text Host controls of HIV broadly neutralizing antibody development JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=28133807 #FOAvip Induction of broadly neutralizing antibodies (bNAbs) is a major goal of HIV vaccine development. BNAbs are made during HIV infection by a subset of individuals but currently cannot be induced in the setting of vaccination. Considerable progress has been made recently in understanding host immunologic controls of bNAb induction and maturation in the setting of HIV infection, and point to key roles for both central and peripheral immunologic tolerance mechanisms in limiting bnAb development. Immune tolerance checkpoint inhibition has been transformative in promotion of anti-tumor CD8 T-cell responses in the treatment of certain malignancies. Here, we review the evidence for host controls of bNAb responses, and discuss strategies for the transient modulation of immune responses with vaccines toward the goal of enhancing germinal center B-cell responses to favor bNAb B-cell lineages and to foster their maturation to full neutralization potency. Twit Text FOAVip Host controls of HIV broadly neutralizing antibody development ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=28133807 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28133807 #FOAvip English Wikipedia <ref>{{Cite pmid|28133807 }}</ref> Host controls of HIV broadly neutralizing antibody development #MMPMID28133807 Kelsoe G ; Haynes BF Immunol Rev 2017[Jan]; 275 (1 ): 79-88 PMID28133807 show ga Induction of broadly neutralizing antibodies (bNAbs) is a major goal of HIV vaccine development. BNAbs are made during HIV infection by a subset of individuals but currently cannot be induced in the setting of vaccination. Considerable progress has been made recently in understanding host immunologic controls of bNAb induction and maturation in the setting of HIV infection, and point to key roles for both central and peripheral immunologic tolerance mechanisms in limiting bnAb development. Immune tolerance checkpoint inhibition has been transformative in promotion of anti-tumor CD8 T-cell responses in the treatment of certain malignancies. Here, we review the evidence for host controls of bNAb responses, and discuss strategies for the transient modulation of immune responses with vaccines toward the goal of enhancing germinal center B-cell responses to favor bNAb B-cell lineages and to foster their maturation to full neutralization potency. |AIDS Vaccines/*immunology [MESH] |Animals [MESH] |Antibodies, Neutralizing/*metabolism [MESH] |B-Lymphocytes/*immunology/virology [MESH] |Cell Differentiation [MESH] |HIV Antibodies/*metabolism [MESH] |HIV Infections/*immunology [MESH] |HIV-1/*immunology [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Immune Tolerance [MESH]Host controls of HIV broadly neutralizing antibody development (epmc).pdf DeepDyve Pubget Overpricing