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2001 ; 55
(ä): 709-42
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Horizontal gene transfer in prokaryotes: quantification and classification
#MMPMID11544372
Koonin EV
; Makarova KS
; Aravind L
Annu Rev Microbiol
2001[]; 55
(ä): 709-42
PMID11544372
show ga
Comparative analysis of bacterial, archaeal, and eukaryotic genomes indicates
that a significant fraction of the genes in the prokaryotic genomes have been
subject to horizontal transfer. In some cases, the amount and source of
horizontal gene transfer can be linked to an organism's lifestyle. For example,
bacterial hyperthermophiles seem to have exchanged genes with archaea to a
greater extent than other bacteria, whereas transfer of certain classes of
eukaryotic genes is most common in parasitic and symbiotic bacteria. Horizontal
transfer events can be classified into distinct categories of acquisition of new
genes, acquisition of paralogs of existing genes, and xenologous gene
displacement whereby a gene is displaced by a horizontally transferred ortholog
from another lineage (xenolog). Each of these types of horizontal gene transfer
is common among prokaryotes, but their relative contributions differ in different
lineages. The fixation and long-term persistence of horizontally transferred
genes suggests that they confer a selective advantage on the recipient organism.
In most cases, the nature of this advantage remains unclear, but detailed
examination of several cases of acquisition of eukaryotic genes by bacteria seems
to reveal the evolutionary forces involved. Examples include isoleucyl-tRNA
synthetases whose acquisition from eukaryotes by several bacteria is linked to
antibiotic resistance, ATP/ADP translocases acquired by intracellular parasitic
bacteria, Chlamydia and Rickettsia, apparently from plants, and proteases that
may be implicated in chlamydial pathogenesis.