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10.1016/j.gde.2013.11.006 http://scihub22266oqcxt.onion/10.1016/j.gde.2013.11.006 C4035381!4035381 !24463272     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24463272 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24463272 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Genet+Dev 2014 ; 25 (ä): 8-14,138 Nephropedia Template TP {{tp|p=24463272 |t=2014. Histone variants: the tricksters of the chromatin world |pdf=|usr=}}{{24463272 }} gab.com Text Histone variants: the tricksters of the chromatin world JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=24463272 #FOAvip The eukaryotic genome exists in vivo at an equimolar ratio with histones, thus forming a polymer composed of DNA and histone proteins. Each nucleosomal unit in this polymer provides versatile capabilities and dynamic range. Substitutions of the individual components of the histone core with structurally distinct histone variants and covalent modifications alter the local fabric of the chromatin fiber, resulting in epigenetic changes that can be regulated by the cell. In this review, we highlight recent advances in the study of histone variant structure, assembly, and inheritance, their influence on nucleosome positioning, and their cumulative effect upon gene expression, DNA repair and the progression of disease. We also highlight fundamental questions that remain unanswered regarding the behavior of histone variants and their influence on cellular function in the normal and diseased states. Twit Text FOAVip Histone variants: the tricksters of the chromatin world ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=24463272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24463272 #FOAvip English Wikipedia <ref>{{Cite pmid|24463272 }}</ref> Histone variants: the tricksters of the chromatin world #MMPMID24463272 Volle C ; Dalal Y Curr Opin Genet Dev 2014[Apr]; 25 (ä): 8-14,138 PMID24463272 show ga The eukaryotic genome exists in vivo at an equimolar ratio with histones, thus forming a polymer composed of DNA and histone proteins. Each nucleosomal unit in this polymer provides versatile capabilities and dynamic range. Substitutions of the individual components of the histone core with structurally distinct histone variants and covalent modifications alter the local fabric of the chromatin fiber, resulting in epigenetic changes that can be regulated by the cell. In this review, we highlight recent advances in the study of histone variant structure, assembly, and inheritance, their influence on nucleosome positioning, and their cumulative effect upon gene expression, DNA repair and the progression of disease. We also highlight fundamental questions that remain unanswered regarding the behavior of histone variants and their influence on cellular function in the normal and diseased states. |Aging [MESH] |Animals [MESH] |Chromatin/*metabolism [MESH] |DNA Repair [MESH] |DNA/metabolism [MESH] |Epigenesis, Genetic [MESH] |Histones/*metabolism [MESH]Histone variants: the tricksters of the chromatin world (epmc).pdf DeepDyve Pubget Overpricing