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2015 ; 16
(12
): 1620-39
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Histone demethylases in chromatin biology and beyond
#MMPMID26564907
Dimitrova E
; Turberfield AH
; Klose RJ
EMBO Rep
2015[Dec]; 16
(12
): 1620-39
PMID26564907
show ga
Histone methylation plays fundamental roles in regulating chromatin-based
processes. With the discovery of histone demethylases over a decade ago, it is
now clear that histone methylation is dynamically regulated to shape the
epigenome and regulate important nuclear processes including transcription, cell
cycle control and DNA repair. In addition, recent observations suggest that these
enzymes could also have functions beyond their originally proposed role as
histone demethylases. In this review, we focus on recent advances in our
understanding of the molecular mechanisms that underpin the role of histone
demethylases in a wide variety of normal cellular processes.