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2016 ; 8
(4
): a019521
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Histone Modifications and Cancer
#MMPMID27037415
Audia JE
; Campbell RM
Cold Spring Harb Perspect Biol
2016[Apr]; 8
(4
): a019521
PMID27037415
show ga
Histone posttranslational modifications represent a versatile set of epigenetic
marks involved not only in dynamic cellular processes, such as transcription and
DNA repair, but also in the stable maintenance of repressive chromatin. In this
article, we review many of the key and newly identified histone modifications
known to be deregulated in cancer and how this impacts function. The latter part
of the article addresses the challenges and current status of the epigenetic drug
development process as it applies to cancer therapeutics.