Hippocampal neurogenesis: Learning to remember
#MMPMID26855369
Lazarov O
; Hollands C
Prog Neurobiol
2016[Mar]; 138-140
(?): 1-18
PMID26855369
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Alzheimer's disease, the most prevalent form of dementia in the elderly, is
characterized by progressive memory loss and cognitive dysfunction. It has become
increasingly clear that while neuronal cell loss in the entorhinal cortex and
hippocampus occurs in Alzheimer's disease, it is preceded by a long period of
deficits in the connectivity of the hippocampal formation that contributes to the
vulnerability of these circuits. Hippocampal neurogenesis plays a role in the
maintenance and function of the dentate gyrus and hippocampal circuitry. This
review will examine the evidence suggesting that hippocampal neurogenesis plays a
role in cognitive function that is affected in Alzheimer's disease, will discuss
the cognitive assessments used for the detection of Alzheimer's disease in humans
and rodent models of familial Alzheimer's disease, and their value for unraveling
the mechanism underlying the development of cognitive impairments and dementia.
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