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2018 ; 51
(3
): 157-162
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Hippo-YAP/TAZ signaling in angiogenesis
#MMPMID29366443
Park JA
; Kwon YG
BMB Rep
2018[Mar]; 51
(3
): 157-162
PMID29366443
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Angiogenesis is a complex, multistep process involving dynamic changes in
endothelial cell (EC) shapes and behaviors, especially in specialized cell types
such as tip cells (with active filopodial extensions), stalk cells (with less
motility) and phalanx cells (with stable junction connections). The
Hippo-Yes-associated protein (YAP)/ transcription activator with PDZ binding
motif (TAZ) signaling plays a critical role in development, regeneration and
organ size by regulating cell-cell contact and actin cytoskeleton dynamics.
Recently, with the finding that YAP is expressed in the front edge of the
developing retinal vessels, Hippo-YAP/TAZ signaling has emerged as a new pathway
for blood vessel development. Intriguingly, the LATS1/2-mediated angiomotin
(AMOT) family and YAP/TAZ activities contribute to EC shapes and behaviors by
spatiotemporally modulating actin cytoskeleton dynamics and EC junction
stability. Herein, we summarize the recent understanding of the role of
Hippo-YAP/TAZ signaling in the processes of EC sprouting and junction maturation
in angiogenesis. [BMB Reports 2018; 51(3): 157-162].
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