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2015 ; 58
(4
): 586-97
Nephropedia Template TP
Mol Cell
2015[May]; 58
(4
): 586-97
PMID26000844
show ga
The human genome sequence has profoundly altered our understanding of biology,
human diversity, and disease. The path from the first draft sequence to our
nascent era of personal genomes and genomic medicine has been made possible only
because of the extraordinary advancements in DNA sequencing technologies over the
past 10 years. Here, we discuss commonly used high-throughput sequencing
platforms, the growing array of sequencing assays developed around them, as well
as the challenges facing current sequencing platforms and their clinical
application.