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2015 ; 472
(3
): 249-59
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High-density lipoprotein mimetics: promises and challenges
#MMPMID26613945
Sviridov D
; Remaley AT
Biochem J
2015[Dec]; 472
(3
): 249-59
PMID26613945
show ga
The concept of lipoprotein mimetics was developed and extensively tested in the
last three decades. Most lipoprotein mimetics were designed to recreate one or
several functions of high-density lipoprotein (HDL) in the context of
cardiovascular disease; however, the application of this approach is much
broader. Lipoprotein mimetics should not just be seen as a set of compounds aimed
at replenishing a deficiency or dysfunctionality of individual elements of
lipoprotein metabolism but rather as a designer concept with remarkable
flexibility and numerous applications in medicine and biology. In the present
review, we discuss the fundamental design principles used to create lipoprotein
mimetics, mechanisms of their action, medical indications and efficacy in animal
models and human studies.