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2017 ; 14
(3
): 2431-2433
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High mobility group box 1 in diabetic nephropathy
#MMPMID28962177
Shi H
; Che Y
; Bai L
; Zhang J
; Fan J
; Mao H
Exp Ther Med
2017[Sep]; 14
(3
): 2431-2433
PMID28962177
show ga
Type 2 diabetes (T2D) is a complex disorder caused by the combined effects of
genetic inheritance and environmental factors. The abnormal secretion of albumin
via urine is the characteristic feature of a diabetic nephropathy (DN) patient.
Moreover, the detection of this observable characteristic feature of DN is quite
late. As a result the time, at which DN is observable, large extent of kidney
damage has already occurred. Thus, this late observation significantly decreases
the chances of efficient management of DN and associated outcomes. The current
biomarker used to detect DN is microalbuminuria, the presence of albumin in the
urine. However, the current biomarkers often lead to false negative results. The
high mobility group box (HMGB)1 is an upcoming molecule being explored for its
application in the management of DN. The present review enlightens the current
status of HMGB1 in DN.