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10.1146/annurev-biochem-060713-035524 http://scihub22266oqcxt.onion/10.1146/annurev-biochem-060713-035524 C4048628!4048628 !24606137     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24606137 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Biochem 2014 ; 83 (ä): 441-66 Nephropedia Template TP {{tp|p=24606137 |t=2014. Hierarchy of RNA functional dynamics |pdf=|usr=}}{{24606137 }} gab.com Text Hierarchy of RNA functional dynamics JO: Annu Rev Biochem http://www.kidney.de/pget.php?&tw=1&pmid=24606137 #FOAvip RNA dynamics play a fundamental role in many cellular functions. However, there is no general framework to describe these complex processes, which typically consist of many structural maneuvers that occur over timescales ranging from picoseconds to seconds. Here, we classify RNA dynamics into distinct modes representing transitions between basins on a hierarchical free-energy landscape. These transitions include large-scale secondary-structural transitions at >0.1-s timescales, base-pair/tertiary dynamics at microsecond-to-millisecond timescales, stacking dynamics at timescales ranging from nanoseconds to microseconds, and other "jittering" motions at timescales ranging from picoseconds to nanoseconds. We review various modes within these three different tiers, the different mechanisms by which they are used to regulate function, and how they can be coupled together to achieve greater functional complexity. Twit Text FOAVip Hierarchy of RNA functional dynamics ????Annu Rev Biochem http://www.kidney.de/pget.php?&tw=1&pmid=24606137 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24606137 #FOAvip English Wikipedia <ref>{{Cite pmid|24606137 }}</ref> Hierarchy of RNA functional dynamics #MMPMID24606137 Mustoe AM ; Brooks CL ; Al-Hashimi HM Annu Rev Biochem 2014[]; 83 (ä): 441-66 PMID24606137 show ga RNA dynamics play a fundamental role in many cellular functions. However, there is no general framework to describe these complex processes, which typically consist of many structural maneuvers that occur over timescales ranging from picoseconds to seconds. Here, we classify RNA dynamics into distinct modes representing transitions between basins on a hierarchical free-energy landscape. These transitions include large-scale secondary-structural transitions at >0.1-s timescales, base-pair/tertiary dynamics at microsecond-to-millisecond timescales, stacking dynamics at timescales ranging from nanoseconds to microseconds, and other "jittering" motions at timescales ranging from picoseconds to nanoseconds. We review various modes within these three different tiers, the different mechanisms by which they are used to regulate function, and how they can be coupled together to achieve greater functional complexity. |*Nucleic Acid Conformation [MESH] |Base Pairing [MESH] |Genetic Techniques [MESH] |Hydrogen-Ion Concentration [MESH] |Kinetics [MESH] |Ligands [MESH] |Magnetic Resonance Spectroscopy [MESH] |Models, Molecular [MESH] |Motion [MESH] |Protein Conformation [MESH] |Proteins/chemistry [MESH] |RNA/*chemistry [MESH] |Temperature [MESH]Hierarchy of RNA functional dynamics (epmc).pdf DeepDyve Pubget Overpricing