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10.1007/s00018-017-2534-9 http://scihub22266oqcxt.onion/10.1007/s00018-017-2534-9 C5589787!5589787 !28523343     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28523343 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28523343 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Life+Sci 2017 ; 74 (19 ): 3481-3490 Nephropedia Template TP {{tp|p=28523343 |t=2017. Hh signaling in regeneration of the ischemic heart |pdf=|usr=}}{{28523343 }} gab.com Text Hh signaling in regeneration of the ischemic heart JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=28523343 #FOAvip Myocardial infarction (MI) is caused by the occlusion of a coronary artery due to underlying atherosclerosis complicated by localized thrombosis. The blockage of blood flow leads to cardiomyocyte (CM) death in the infarcted area. Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury; however, some pathways active during embryogenesis and silent during adult life are recruited in response to tissue injury. One such example is hedgehog (Hh) signaling. Hh is involved in the embryonic development of the heart and coronary vascular system. Pathological conditions including ischemia activate Hh signaling in adult tissues. This review highlights the involvement of Hh signaling in ischemic tissue regeneration with a particular emphasis on heart regeneration and discusses its potential role as a therapeutic agent. Twit Text FOAVip Hh signaling in regeneration of the ischemic heart ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=28523343 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28523343 #FOAvip English Wikipedia <ref>{{Cite pmid|28523343 }}</ref> Hh signaling in regeneration of the ischemic heart #MMPMID28523343 Dunaeva M ; Waltenberger J Cell Mol Life Sci 2017[Oct]; 74 (19 ): 3481-3490 PMID28523343 show ga Myocardial infarction (MI) is caused by the occlusion of a coronary artery due to underlying atherosclerosis complicated by localized thrombosis. The blockage of blood flow leads to cardiomyocyte (CM) death in the infarcted area. Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury; however, some pathways active during embryogenesis and silent during adult life are recruited in response to tissue injury. One such example is hedgehog (Hh) signaling. Hh is involved in the embryonic development of the heart and coronary vascular system. Pathological conditions including ischemia activate Hh signaling in adult tissues. This review highlights the involvement of Hh signaling in ischemic tissue regeneration with a particular emphasis on heart regeneration and discusses its potential role as a therapeutic agent. |*Regeneration/drug effects [MESH] |*Signal Transduction/drug effects [MESH] |Animals [MESH] |Cell- and Tissue-Based Therapy/methods [MESH] |Cellular Reprogramming Techniques/methods [MESH] |Drug Discovery [MESH] |Heart/drug effects/*physiology [MESH] |Hedgehog Proteins/agonists/*metabolism [MESH] |Humans [MESH] |Molecular Targeted Therapy [MESH] |Myocardial Ischemia/*metabolism/*therapy [MESH]Hh signaling in regeneration of the ischemic heart (epmc).pdf DeepDyve Pubget Overpricing